Diagnostic Importance of PAX2, ARID1A, and FOXA1 Biomarkers in Atypical Endometrial Hyperplasia.
J Coll Physicians Surg Pak
; 33(8): 847-851, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37553920
ABSTRACT
OBJECTIVE:
To evaluate the contribution of PAX2, ARID1A, and FOXA1 biomarkers to diagnosis in cases with atypical endometrial hyperplasia (AEH). STUDYDESIGN:
Descriptive Study. Place and Duration of the Study Pathology Department of Umraniye Training and Research Hospital, from January 2018 to December 2020.METHODOLOGY:
Curettage materials of 100 patients diagnosed with AEH which stained PAX2, ARID1A, and FOXA1, were evaluated. The staining patterns in the atypical endometrial glandular areas were grouped as slight-no loss, moderate loss, and complete loss / severe loss for all three biomarkers. Complete or/severe loss in AEH was considered helpful in the diagnosis.RESULTS:
Complete loss / severe loss rates in curettages were 84% for PAX2, 5% for ARID1A, and 15% for FOXA1, respectively. When used in combination, complete loss / severe loss rates were 85% in at least one of the three markers, 84% in PAX2 and/or ARID1A, 85% in PAX2 and/or FOXA1, and 17% in ARID1A and/or FOXA1.CONCLUSION:
Although all 3 biomarkers showed marked staining loss, PAX2 is the most sensitive biomarker for the diagnosis of AEH in curettage materials. KEY WORDS Endometrium, Atypical hyperplasia, PAX2, ARID1A, FOXA1.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias do Endométrio
/
Hiperplasia Endometrial
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Coll Physicians Surg Pak
Assunto da revista:
MEDICINA
Ano de publicação:
2023
Tipo de documento:
Article