Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer.

Schmidt, Daniel R; Gramatikov, Iva Monique T; Sheen, Allison; Williams, Christopher L; Hurwitz, Martina; Dodge, Laura E; Holupka, Edward; Kiger, W S; Cornwall-Brady, Milton R; Huang, Wei; Mak, Howard H; Cormier, Kathleen S; Condon, Charlene; Dane Wittrup, K; Yilmaz, Ömer H; Stevenson, Mary Ann; Down, Julian D; Floyd, Scott R; Roper, Jatin; Vander Heiden, Matthew G

Schmidt, Daniel R; Gramatikov, Iva Monique T; Sheen, Allison; Williams, Christopher L; Hurwitz, Martina; Dodge, Laura E; Holupka, Edward; Kiger, W S; Cornwall-Brady, Milton R; Huang, Wei; Mak, Howard H; Cormier, Kathleen S; Condon, Charlene; Dane Wittrup, K; Yilmaz, Ömer H; Stevenson, Mary Ann; Down, Julian D; Floyd, Scott R; Roper, Jatin; Vander Heiden, Matthew G.

Afiliação

Schmidt DR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. dschmidt@bidmc.harvard.edu.
Gramatikov IMT; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. dschmidt@bidmc.harvard.edu.
Sheen A; Harvard Medical School, Boston, MA, USA. dschmidt@bidmc.harvard.edu.
Williams CL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hurwitz M; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Dodge LE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Holupka E; Harvard Medical School, Boston, MA, USA.
Kiger WS; Dana-Farber Cancer Institute, Boston, MA, USA.
Cornwall-Brady MR; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA.
Huang W; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Mak HH; Harvard Medical School, Boston, MA, USA.
Cormier KS; Harvard Medical School, Boston, MA, USA.
Condon C; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Dane Wittrup K; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Yilmaz ÖH; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Stevenson MA; Harvard Medical School, Boston, MA, USA.
Down JD; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Floyd SR; Harvard Medical School, Boston, MA, USA.
Roper J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Commun Med (Lond) ; 3(1): 108, 2023 Aug 09.

Article em En | MEDLINE | ID: mdl-37558833

Mice can be used to model the types of cancer seen in people to investigate the effects of cancer therapies, such as radiation. Here, we apply radiation therapy treatments that are able to cure cancer in humans to mice that have cancer of the prostate or colorectum. We show that the mice do not experience many side effects and that the tumours reduce in size, but in some cases show progression after treatment. Our study demonstrates that mice can be used to better understand how human cancers respond to radiation treatment, which can lead to the development of improved treatments and treatment schedules.

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Commun Med (Lond) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos