How to Modulate Peripheral and Central Nervous System to Treat Acute Postoperative Pain and Prevent Pain Persistence.
Curr Neuropharmacol
; 22(1): 23-37, 2024.
Article
em En
| MEDLINE
| ID: mdl-37563811
ABSTRACT
Chronic postoperative pain (CPSP) is a major issue after surgery, which may impact on patient's quality of life. Traditionally, CPSP is believed to rely on maladaptive hyperalgesia and risk factors have been identified that predispose to CPSP, including acute postoperative pain. Despite new models of prediction are emerging, acute pain is still a modifiable factor that can be challenged with perioperative analgesic strategies. In this review we present the issue of CPSP, focusing on molecular mechanism underlying the development of acute and chronic hyperalgesia. Also, we focus on how perioperative strategies can impact directly or indirectly (by reducing postoperative pain intensity) on the development of CPSP.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Dor Crônica
/
Hiperalgesia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Neuropharmacol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália