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The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania.
Leta, Tesfaye H; Fenstad, Anne Marie; Lygre, Stein Håkon L; Lie, Stein Atle; Lindberg-Larsen, Martin; Pedersen, Alma B; W-Dahl, Annette; Rolfson, Ola; Bülow, Erik; Ashforth, James A; Van Steenbergen, Liza N; Nelissen, Rob G H H; Harries, Dylan; De Steiger, Richard; Lutro, Olav; Hakulinen, Emmi; Mäkelä, Keijo; Willis, Jinny; Wyatt, Michael; Frampton, Chris; Grimberg, Alexander; Steinbrück, Arnd; Wu, Yinan; Armaroli, Cristiana; Molinari, Marco; Picus, Roberto; Mullen, Kyle; Illgen, Richard; Stoica, Ioan C; Vorovenci, Andreea E; Dragomirescu, Dan; Dale, Håvard; Brand, Christian; Christen, Bernhard; Shapiro, Joanne; Wilkinson, J Mark; Armstrong, Richard; Wooster, Kate; Hallan, Geir; Gjertsen, Jan-Erik; Chang, Richard N; Prentice, Heather A; Paxton, Elizabeth W; Furnes, Ove.
Afiliação
  • Leta TH; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Faculty of Health Science, VID Specialized University, Norway; Department of Population Health Sciences, Weill Medical College of Cornell University, USA; Department of Medical Device Survei
  • Fenstad AM; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway.
  • Lygre SHL; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Occupational Medicine, Haukeland University Hospital, Norway.
  • Lie SA; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Institutes of Dentistry, University of Bergen, Norway.
  • Lindberg-Larsen M; The Danish Knee Arthroplasty Register, Denmark; Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Denmark.
  • Pedersen AB; The Danish Knee Arthroplasty Register, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Denmark.
  • W-Dahl A; The Swedish Arthroplasty Register, Sweden; Department of Clinical Sciences Lund, Division of Orthopedics, Lund University, Lund, Sweden.
  • Rolfson O; The Swedish Arthroplasty Register, Sweden; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Bülow E; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Centre of Registers Västra Götaland, Gothenburg, Sweden.
  • Ashforth JA; JointCare Registry, South Africa.
  • Van Steenbergen LN; The Dutch Arthroplasty Register, the Netherlands.
  • Nelissen RGHH; The Dutch Arthroplasty Register, the Netherlands; Department of Orthopedics, Leiden University Medical Center, the Netherlands.
  • Harries D; South Australian Health and Medical Research Institute, Australia.
  • De Steiger R; The Australian Orthopaedic Association National Joint Replacement Registry, Australia.
  • Lutro O; Department of Medicine, Stavanger University Hospital, Norway.
  • Hakulinen E; The Finnish Institute for Health and Welfare, Finland.
  • Mäkelä K; The Finnish Arthroplasty Register, Finland; Turku University Hospital and University of Turku, Turku, Finland.
  • Willis J; The New Zealand Joint Registry, New Zealand.
  • Wyatt M; The New Zealand Joint Registry, New Zealand.
  • Frampton C; The New Zealand Joint Registry, New Zealand.
  • Grimberg A; The Germany Arthroplasty Registry, Germany.
  • Steinbrück A; The Germany Arthroplasty Registry, Germany.
  • Wu Y; The Germany Arthroplasty Registry, Germany.
  • Armaroli C; Arthroplasty Registry of the Autonomous Province of Trento (PATN), Clinical Epidemiology Service, Provincial Agency for Health Services of Trento (APSS), Italy.
  • Molinari M; Orthopedics and Traumatology Operative Unit, Cavalese Hospital, Provincial Agency for Health Services of Trento (APSS), Italy.
  • Picus R; Arthroplasty Register of Autonomous Province of Bolzano (PABZ), Observatory of Health, Health Department AP of Bolzano, Italy.
  • Mullen K; American Joint Replacement Registry, USA.
  • Illgen R; American Joint Replacement Registry, USA; University of Wisconsin-Madison School of Medicine and Public Health, Department of Orthopedic Surgery and Rehabilitation, USA.
  • Stoica IC; Romanian Arthroplasty Registry, Romania; University of Medicine and Pharmacy - Carol Davila - Bucharest - UMFCD Bucharest, Romania; Foisor Orthopedic Hospital, Romania.
  • Vorovenci AE; Romanian Arthroplasty Registry, Romania; Economic Cybernetics and Statistics Doctoral School, Bucharest University of Economic Studies, Romania.
  • Dragomirescu D; Romanian Arthroplasty Registry, Romania; Economic Cybernetics and Statistics Doctoral School, Bucharest University of Economic Studies, Romania.
  • Dale H; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway.
  • Brand C; Swiss National Hip & Knee Joint Registry, Switzerland; Institute of Social and Preventive Medicine, SwissRDL, University of Bern; Switzerland.
  • Christen B; Swiss National Hip & Knee Joint Registry, Switzerland; Articon, Bern, Switzerland.
  • Shapiro J; The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; NEC Software Solutions, Hemel Hempstead, UK.
  • Wilkinson JM; The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
  • Armstrong R; The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; NEC Software Solutions, Hemel Hempstead, UK.
  • Wooster K; The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; NEC Software Solutions, Hemel Hempstead, UK.
  • Hallan G; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway.
  • Gjertsen JE; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway.
  • Chang RN; Medical Device Surveillance & Assessment, Kaiser Permanente, USA.
  • Prentice HA; Medical Device Surveillance & Assessment, Kaiser Permanente, USA.
  • Paxton EW; Medical Device Surveillance & Assessment, Kaiser Permanente, USA.
  • Furnes O; The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway.
Acta Orthop ; 94: 416-425, 2023 08 09.
Article em En | MEDLINE | ID: mdl-37565339
ABSTRACT
BACKGROUND AND

PURPOSE:

Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA). PATIENTS AND

METHODS:

This observational study is based on 2,971,357 primary TKAs reported in 2010-2020 to national/regional joint arthroplasty registries in Australia, Denmark, Finland, Germany, Italy, the Netherlands, New Zealand, Norway, Romania, South Africa, Sweden, Switzerland, the UK, and the USA. Aggregate-level data on trends and types of bone cement, antibiotic agents, and doses and duration of SAP used was extracted from participating registries.

RESULTS:

ALBC was used in 77% of the TKAs with variation ranging from 100% in Norway to 31% in the USA. Palacos R+G was the most common (62%) ALBC type used. The primary antibiotic used in ALBC was gentamicin (94%). Use of ALBC in combination with SAP was common practice (77%). Cefazolin was the most common (32%) SAP agent. The doses and duration of SAP used varied from one single preoperative dosage as standard practice in Bolzano, Italy (98%) to 1-day 4 doses in Norway (83% of the 40,709 TKAs reported to the Norwegian arthroplasty register).

CONCLUSION:

The proportion of ALBC usage in primary TKA varies internationally, with gentamicin being the most common antibiotic. ALBC in combination with SAP was common practice, with cefazolin the most common SAP agent. The type of ALBC and type, dose, and duration of SAP varied among participating countries.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções Relacionadas à Prótese / Artroplastia do Joelho Tipo de estudo: Observational_studies Limite: Humans País/Região como assunto: Africa / America do norte / Europa / Oceania Idioma: En Revista: Acta Orthop Assunto da revista: ORTOPEDIA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Infecções Relacionadas à Prótese / Artroplastia do Joelho Tipo de estudo: Observational_studies Limite: Humans País/Região como assunto: Africa / America do norte / Europa / Oceania Idioma: En Revista: Acta Orthop Assunto da revista: ORTOPEDIA Ano de publicação: 2023 Tipo de documento: Article