Krebs von den Lungen-6 as a Potential Predictive Biomarker in Fibrosing Interstitial Lung Diseases.
Respiration
; 102(8): 591-600, 2023.
Article
em En
| MEDLINE
| ID: mdl-37586349
ABSTRACT
BACKGROUND:
As fibrosing interstitial lung diseases (fILDs) are associated with high mortality, monitoring of disease activity under treatment is highly relevant. Krebs von den Lungen-6 (KL-6) is associated with the presence and severity of different fILDs, mainly in Asian patient populations.OBJECTIVES:
Our aim was to evaluate KL-6 as a predictive biomarker in fILDs in Caucasian patients.METHODS:
Consecutive patients with fILDs were recruited prospectively and serum concentrations of KL-6 were measured at baseline (BL), after 6 and 12 months (6 Months, 12 Months). Clinical characteristics including pulmonary function tests were assessed at 6-monthly visits and correlated with KL-6 BL levels as well as with KL-6 level changes.RESULTS:
A total of 47 fILD patients were included (mean age 65 years, 68% male). KL-6 levels at BL were significantly higher in fILD patients than in healthy controls (n = 44, mean age 45, 23% male) (ILD 1,757 ± 1960 U/mL vs. control 265 ± 107 U/mL, p < 0.0001). However, no differences were noted between ILD subgroups. KL-6 decreased significantly under therapy (6M∆BL-KL6 -486 ± 1,505 mean U/mL, p = 0.032; 12M∆BL-KL6 -547 ± 1,782 mean U/mL, p = 0.041) and KL-6 level changes were negatively correlated with changes in pulmonary function parameters (forced vital capacity [FVC] r = -0.562, p < 0.0001; DLCOSB r = -0.405, p = 0.013). While neither absolute KL-6 levels at BL nor KL-6 level changes were associated with ILD progression (FVC decline ≥10%, DLCOSB decline ≥15% or death), patients with a stable FVC showed significantly decreasing KL-6 levels (p = 0.022).CONCLUSIONS:
A decline of KL-6 under therapy correlated with a clinically relevant stabilization of lung function. Thus, KL-6 might serve as a predictive biomarker, which however must be determined by larger prospective cohorts.Palavras-chave
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Bases de dados:
MEDLINE
Assunto principal:
Doenças Pulmonares Intersticiais
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Respiration
Ano de publicação:
2023
Tipo de documento:
Article