The protective effects of sesamol and/or the probiotic, <i>Lactobacillus rhamnosus</i>, against aluminum chloride-induced neurotoxicity and hepatotoxicity in rats: Modulation of Wnt/ß-catenin/GSK-3ß, JAK-2/STAT-3, PPAR-Î³, inflammatory, and apoptotic pathways.

Abu-Elfotuh, Karema; Selim, Heba Mohammed Refat M; Riad, Omnia Karem M; Hamdan, Ahmed M E; Hassanin, Soha Osama; Sharif, Asmaa F; Moustafa, Nouran Magdy; Gowifel, Ayah M H; Mohamed, Marwa Y A; Atwa, Ahmed M; Zaghlool, Sameh S; El-Din, Mahmoud Nour

The protective effects of sesamol and/or the probiotic, Lactobacillus rhamnosus, against aluminum chloride-induced neurotoxicity and hepatotoxicity in rats: Modulation of Wnt/ß-catenin/GSK-3ß, JAK-2/STAT-3, PPAR-Î³, inflammatory, and apoptotic pathways.

Abu-Elfotuh, Karema; Selim, Heba Mohammed Refat M; Riad, Omnia Karem M; Hamdan, Ahmed M E; Hassanin, Soha Osama; Sharif, Asmaa F; Moustafa, Nouran Magdy; Gowifel, Ayah M H; Mohamed, Marwa Y A; Atwa, Ahmed M; Zaghlool, Sameh S; El-Din, Mahmoud Nour.

Afiliação

Abu-Elfotuh K; Clinical Pharmacy Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Selim HMRM; Pharmaceutical Sciences Department, Faculty of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Riad OKM; Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Hamdan AME; Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Hassanin SO; Pharmacy Practice Department, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Sharif AF; Biochemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.
Moustafa NM; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Gowifel AMH; Clinical Medical Sciences Department, College of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia.
Mohamed MYA; Basic Medical Science Department, College of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia.
Atwa AM; Medical Microbiology and Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Zaghlool SS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.
El-Din MN; Biology Department, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Front Pharmacol ; 14: 1208252, 2023.

Article em En | MEDLINE | ID: mdl-37601053

Palavras-chave

AlCl3; JAK-2/STAT-3; Lactobacillus rhamnosus; PPAR-Î³; Wnt/ß-catenin/GSK-3ß; neurotoxicity; probiotic; sesamol

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Egito