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The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease.
Goul, Claire; Peruzzo, Roberta; Zoncu, Roberto.
Afiliação
  • Goul C; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
  • Peruzzo R; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
  • Zoncu R; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. rzoncu@berkeley.edu.
Nat Rev Mol Cell Biol ; 24(12): 857-875, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37612414
The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such as the levels of nutrients, growth factors, energy sources and oxygen, and triggers responses that either boost anabolism or suppress catabolism. mTORC1 signalling has wide-ranging consequences for the growth and homeostasis of key tissues and organs, and its dysregulated activity promotes cancer, type 2 diabetes, neurodegeneration and other age-related disorders. How mTORC1 integrates numerous upstream cues and translates them into specific downstream responses is an outstanding question with major implications for our understanding of physiology and disease mechanisms. In this Review, we discuss recent structural and functional insights into the molecular architecture of mTORC1 and its lysosomal partners, which have greatly increased our mechanistic understanding of nutrient-dependent mTORC1 regulation. We also discuss the emerging involvement of aberrant nutrient-mTORC1 signalling in multiple diseases.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Complexos Multiproteicos / Diabetes Mellitus Tipo 2 Limite: Humans Idioma: En Revista: Nat Rev Mol Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Complexos Multiproteicos / Diabetes Mellitus Tipo 2 Limite: Humans Idioma: En Revista: Nat Rev Mol Cell Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos