N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody.

Zibat, Arne; Zhang, Xiaoxiao; Dickmanns, Antje; Stegmann, Kim M; Dobbelstein, Adrian W; Alachram, Halima; Soliwoda, Rebecca; Salinas, Gabriela; Groß, Uwe; Görlich, Dirk; Kschischo, Maik; Wollnik, Bernd; Dobbelstein, Matthias

Zibat, Arne; Zhang, Xiaoxiao; Dickmanns, Antje; Stegmann, Kim M; Dobbelstein, Adrian W; Alachram, Halima; Soliwoda, Rebecca; Salinas, Gabriela; Groß, Uwe; Görlich, Dirk; Kschischo, Maik; Wollnik, Bernd; Dobbelstein, Matthias.

Afiliação

Zibat A; Department of Human Genetics, University Medical Center Göttingen, 37073 Göttingen, Germany.
Zhang X; Department of Mathematics and Technology, University of Applied Sciences Koblenz, 53424 Remagen, Germany.
Dickmanns A; Department of Informatics, Technical University of Munich, 81675 Munich, Germany.
Stegmann KM; Department of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, 37077 Göttingen, Germany.
Dobbelstein AW; Department of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, 37077 Göttingen, Germany.
Alachram H; Max Planck Institute for Biology, 72076 Tübingen, Germany.
Soliwoda R; Department of Human Genetics, University Medical Center Göttingen, 37073 Göttingen, Germany.
Salinas G; Department of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, 37077 Göttingen, Germany.
Groß U; NGS Integrative Genomics Core Unit, Department of Human Genetics, University Medical Center Göttingen, 37077 Göttingen, Germany.
Görlich D; Department of Medical Microbiology and Virology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Kschischo M; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.
Wollnik B; Department of Mathematics and Technology, University of Applied Sciences Koblenz, 53424 Remagen, Germany.
Dobbelstein M; Department of Human Genetics, University Medical Center Göttingen, 37073 Göttingen, Germany.

iScience ; 26(10): 107786, 2023 Oct 20.

Article em En | MEDLINE | ID: mdl-37731621

Palavras-chave

Immunology; Pharmaceutical science; Structural biology; Virology

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha