Night-to-night variability in sleep and amyloid beta burden in normal aging.
Alzheimers Dement (Amst)
; 15(3): e12460, 2023.
Article
em En
| MEDLINE
| ID: mdl-37745892
ABSTRACT
INTRODUCTION:
Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy-detected sleep parameters might be biomarkers for early amyloid burden.METHODS:
Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid-positive and amyloid-negative participants. Then multiple linear regressions were used between mean or night-to-night intra-individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel-wise analysis.RESULTS:
Eighty-six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid-positive participants had a higher variability of sleep fragmentation compared to amyloid-negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample.DISCUSSION:
This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Alzheimers Dement (Amst)
Ano de publicação:
2023
Tipo de documento:
Article