The roles of intracellular proteolysis in cardiac ischemia-reperfusion injury.
Basic Res Cardiol
; 118(1): 38, 2023 09 28.
Article
em En
| MEDLINE
| ID: mdl-37768438
ABSTRACT
Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemia-reperfusion injury caused by the reintroduction of blood supply to ischemic cardiac muscle. The short and long-term damage that occurs due to ischemia-reperfusion injury is partly due to the proteolysis of diverse protein substrates inside and outside of cardiomyocytes. Ischemia-reperfusion activates several diverse intracellular proteases, including, but not limited to, matrix metalloproteinases, calpains, cathepsins, and caspases. This review will focus on the biological roles, intracellular localization, proteolytic targets, and inhibitors of these proteases in cardiomyocytes following ischemia-reperfusion injury. Recognition of the intracellular function of each of these proteases includes defining their activation, proteolytic targets, and their inhibitors during myocardial ischemia-reperfusion injury. This review is a step toward a better understanding of protease activation and involvement in ischemic heart disease and developing new therapeutic strategies for its treatment.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão Miocárdica
/
Isquemia Miocárdica
Limite:
Humans
Idioma:
En
Revista:
Basic Res Cardiol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Canadá