Effect of perfusate hematocrit on urea permeability-surface area in isolated dog lung.
J Appl Physiol (1985)
; 61(4): 1383-7, 1986 Oct.
Article
em En
| MEDLINE
| ID: mdl-3781954
ABSTRACT
Seven dog lower left lung lobes were statically inflated and perfused at a constant rate for each lobe with a perfusate in which the hematocrit was altered over a wide range. The permeability-surface area of urea was calculated from multiple indicator dilution curves using two separate injectates for each hematocrit level. One injectate contained only 125I-albumin as the vascular reference tracer and the other contained both 51Cr-erythrocytes and 125I-albumin as the vascular reference tracers; both contained [14C]urea as the permeating tracer. The results strongly indicate that the phenomenon of "erythrocyte trapping" of urea does not affect the calculation of urea permeability-surface area product provided the appropriate albumin-erythrocyte composite reference tracer is utilized in its calculation.
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Bases de dados:
MEDLINE
Assunto principal:
Ureia
/
Permeabilidade da Membrana Celular
/
Hematócrito
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
J Appl Physiol (1985)
Assunto da revista:
FISIOLOGIA
Ano de publicação:
1986
Tipo de documento:
Article