Scutellarin ameliorates diabetic nephropathy via TGF-ß1 signaling pathway.
Biol Pharm Bull
; 2023 Oct 17.
Article
em En
| MEDLINE
| ID: mdl-37853616
ABSTRACT
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin-induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the TGF-ß1 signaling pathway, as well as its interaction with the Erk and Wnt/ß-catenin pathways.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Biol Pharm Bull
Assunto da revista:
BIOQUIMICA
/
FARMACOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article