Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8<sup>+</sup> T Cells and Causes Immunopathology in Response to Acute LCMV Infection.

Friebus-Kardash, Justa; Christ, Theresa Charlotte; Dietlein, Nikolaus; Elwy, Abdelrahman; Abdelrahman, Hossam; Holnsteiner, Lisa; Hu, Zhongwen; Rodewald, Hans-Reimer; Lang, Karl Sebastian

Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8⁺ T Cells and Causes Immunopathology in Response to Acute LCMV Infection.

Friebus-Kardash, Justa; Christ, Theresa Charlotte; Dietlein, Nikolaus; Elwy, Abdelrahman; Abdelrahman, Hossam; Holnsteiner, Lisa; Hu, Zhongwen; Rodewald, Hans-Reimer; Lang, Karl Sebastian.

Afiliação

Friebus-Kardash J; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Christ TC; Department of Nephrology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Dietlein N; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Elwy A; Division of Cellular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany.
Abdelrahman H; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Holnsteiner L; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Hu Z; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Rodewald HR; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany.
Lang KS; Division of Cellular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany.

Vaccines (Basel) ; 11(10)2023 Oct 05.

Article em En | MEDLINE | ID: mdl-37896966

Palavras-chave

LCMV; PD-L1 downregulation; activation of CD8+ T cells; liver failure; ubiquitin-specific peptidase 22 (Usp22)

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Vaccines (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha