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The fourth COVID-19 vaccine dose increased the neutralizing antibody response against the SARS-CoV-2 Omicron (B.1.1.529) variant in a diverse Brazilian population.
Pires Farias, Jéssica; Andreata-Santos, Robert; Dalety da Silva Brito, Ruth; Silva Souza, Milena; Moreira Costa Fogaça, Mayanna; Ramos Pinheiro, Josilene; Ferreira da Cruz, Edgar; Liang, Willian; Simões, Rafael da Conceição; Barros Luiz, Wilson; Birbrair, Alexander; Oliveira Vidal, Paloma; Terzi Maricato, Juliana; Torres Braconi, Carla; Ferreira, Luís Carlos de Souza; Ramos Janini, Luiz Mário; Amorim, Jaime Henrique.
Afiliação
  • Pires Farias J; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Andreata-Santos R; Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP) , São Paulo, São Paulo, Brazil.
  • Dalety da Silva Brito R; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Silva Souza M; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Moreira Costa Fogaça M; Department of Biological Sciences, State University of Santa Cruz , Ilhéus, Bahia, Brazil.
  • Ramos Pinheiro J; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Ferreira da Cruz E; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Liang W; Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP) , São Paulo, São Paulo, Brazil.
  • Simões RdC; Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP) , São Paulo, São Paulo, Brazil.
  • Barros Luiz W; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Birbrair A; Department of Biological Sciences, State University of Santa Cruz , Ilhéus, Bahia, Brazil.
  • Oliveira Vidal P; Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Terzi Maricato J; Department of Pathology, Federal University of Minas Gerais , Belo Horizonte, Minas Gerais, Brazil.
  • Torres Braconi C; Department of Radiology, Columbia University Medical Center , New York, New York, USA.
  • Ferreira LCdS; Western Bahia Virology Institute, Center of Biological Sciences and Health, Federal University of Western Bahia , Barreiras, Bahia, Brazil.
  • Ramos Janini LM; Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP) , São Paulo, São Paulo, Brazil.
  • Amorim JH; Department of Microbiology, Immunology and Parasitology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP) , São Paulo, São Paulo, Brazil.
Microbiol Spectr ; 11(6): e0285723, 2023 Dec 12.
Article em En | MEDLINE | ID: mdl-37909777
ABSTRACT
IMPORTANCE Several additional COVID-19 vaccine doses were administered in the Brazilian population to prevent the disease caused by the B.1.1.529 (Omicron) variant. The efficacy of a third dose as a booster is already well described. However, it is important to clarify the humoral immune response gain induced by a fourth dose. In this study, we evaluate the effect of the fourth COVID-19 vaccine dose in a diverse Brazilian population, considering a real-life context. Our study reveals that the fourth dose of the COVID-19 vaccine increased the neutralizing antibody response against SARS-CoV-2 Omicron and significantly contributed in the reduction of the disease caused by this variant.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Microbiol Spectr Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Microbiol Spectr Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil