Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition.

Verkade, Esther; Shen, Wenqiang; Hovingh, Milaine V; Mulder, Niels L; de Bruyn, Krisztina; Koehorst, Martijn; de Vries, Hilde D; Bloks, Vincent W; Kuipers, Folkert; de Boer, Jan Freark

Verkade, Esther; Shen, Wenqiang; Hovingh, Milaine V; Mulder, Niels L; de Bruyn, Krisztina; Koehorst, Martijn; de Vries, Hilde D; Bloks, Vincent W; Kuipers, Folkert; de Boer, Jan Freark.

Afiliação

Verkade E; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Shen W; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hovingh MV; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Mulder NL; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
de Bruyn K; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Koehorst M; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
de Vries HD; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bloks VW; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Kuipers F; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
de Boer JF; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Clin Sci (Lond) ; 137(21): 1637-1650, 2023 11 15.

Article em En | MEDLINE | ID: mdl-37910096

Assuntos

Colestase; Microbioma Gastrointestinal; Humanos; Masculino; Animais; Feminino; Camundongos; Ácidos e Sais Biliares/metabolismo; Esteroide 12-alfa-Hidroxilase/genética; Esteroide 12-alfa-Hidroxilase/metabolismo; Fígado/metabolismo; Antibacterianos; Camundongos Endogâmicos C57BL

Palavras-chave

Cyp2c70; bile acids; gut microbiota; hepatobiliary disease; hydrophobicity; liver fibrosis

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Colestase / Microbioma Gastrointestinal Limite: Animals / Female / Humans / Male Idioma: En Revista: Clin Sci (Lond) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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