hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.

Zhang, Qiao; Weng, Weiji; Gu, Xiaokun; Xiang, Jinhua; Yang, Yang; Zhu, Michael X; Gu, Weidong; He, Zhenzhou; Li, Yong

Zhang, Qiao; Weng, Weiji; Gu, Xiaokun; Xiang, Jinhua; Yang, Yang; Zhu, Michael X; Gu, Weidong; He, Zhenzhou; Li, Yong.

Afiliação

Zhang Q; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Weng W; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Gu X; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiang J; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yang Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhu MX; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Gu W; Department of Anesthesiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China. Electronic address: mcwgwd@163.com.
He Z; Department of Anesthesiology, Minhang Hospital Affiliated to Fudan University, Shanghai 201199, China. Electronic address: hezhenzhou@fudan.edu.cn.
Li Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: liyong68@shsmu.edu.cn.

Cell Rep ; 42(11): 113401, 2023 11 28.

Article em En | MEDLINE | ID: mdl-37943660

Assuntos

Dor Crônica; Sumoilação; Animais; Camundongos; Dor Crônica/metabolismo; Adjuvante de Freund; Gânglios Espinais/metabolismo; Hiperalgesia/metabolismo; Inflamação/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Canal de Cátion TRPA1/genética; Canal de Cátion TRPA1/metabolismo

Palavras-chave

CP: Neuroscience; TRPA1 expression; cold hypersensitivity in chronic inflammatory pain; hnRNPA1 SUMOylation; mRNA stability

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Sumoilação / Dor Crônica Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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