Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles.
Microbiome
; 11(1): 249, 2023 11 13.
Article
em En
| MEDLINE
| ID: mdl-37953319
ABSTRACT
BACKGROUND:
Reports regarding the presence of bacteria in the fetal environment remain limited and controversial. Recently, extracellular vesicles secreted by the human gut microbiota have emerged as a novel mechanism for host-microbiota interaction. We aimed to investigate the presence of bacterial extracellular vesicles in the fetal environment during healthy pregnancies and determine whether extracellular vesicles derived from the gut microbiota can cross biological barriers to reach the fetus.RESULTS:
Bacterial extracellular vesicles were detectable in the amniotic fluid of healthy pregnant women, exhibiting similarities to extracellular vesicles found in the maternal gut microbiota. In pregnant mice, extracellular vesicles derived from human maternal gut microbiota were found to reach the intra-amniotic space.CONCLUSIONS:
Our findings reveal maternal microbiota-derived extracellular vesicles as an interaction mechanism between the maternal microbiota and fetus, potentially playing a pivotal role in priming the prenatal immune system for gut colonization after birth. Video Abstract.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Microbiota
/
Vesículas Extracelulares
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Microbioma Gastrointestinal
Limite:
Animals
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Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Microbiome
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Finlândia