Silicon-Carbon Dots-Loaded Mesoporous Silica Nanocomposites (mSiO<sub>2</sub>@SiCDs): An Efficient Dual Inhibitor of Cu<sup>2+</sup>-Mediated Oxidative Stress and Aß Aggregation for Alzheimer's Disease.

Li, Qin-Ying; Yu, Xu; Li, Xi; Bao, Li-Na; Zhang, Yu; Xie, Min-Jie; Jiang, Ming; Wang, Ya Qian; Huang, Kun; Xu, Li

Silicon-Carbon Dots-Loaded Mesoporous Silica Nanocomposites (mSiO₂@SiCDs): An Efficient Dual Inhibitor of Cu²⁺-Mediated Oxidative Stress and Aß Aggregation for Alzheimer's Disease.

Li, Qin-Ying; Yu, Xu; Li, Xi; Bao, Li-Na; Zhang, Yu; Xie, Min-Jie; Jiang, Ming; Wang, Ya Qian; Huang, Kun; Xu, Li.

Afiliação

Li QY; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Yu X; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li X; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Bao LN; Hubei Jiangxia Laboratory, Wuhan 430200, China.
Zhang Y; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Xie MJ; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiang M; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang YQ; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.
Huang K; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Xu L; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.

ACS Appl Mater Interfaces ; 15(47): 54221-54233, 2023 Nov 29.

Article em En | MEDLINE | ID: mdl-37962427

Assuntos

Doença de Alzheimer; Humanos; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/patologia; Silício/uso terapêutico; Silanos; Dióxido de Silício/uso terapêutico; Carbono/uso terapêutico; Cobre/farmacologia; Peptídeos beta-Amiloides/metabolismo; Estresse Oxidativo; Metais; Quelantes/farmacologia

Palavras-chave

Alzheimer's disease; Cu2+ chelation; mesoporous silica nanoparticles; siliconcarbon dots; ß-amyloid

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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