Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.

Cai, Tingwen; Chen, Siyuan; Wu, Chenghu; Lou, Chao; Wang, Weidan; Lin, Chihao; Jiang, Hongyi; Xu, Xinxian

Cai, Tingwen; Chen, Siyuan; Wu, Chenghu; Lou, Chao; Wang, Weidan; Lin, Chihao; Jiang, Hongyi; Xu, Xinxian.

Afiliação

Cai T; Department of Orthopedics, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Chen S; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China.
Wu C; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Lou C; Department of Orthopedics, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Wang W; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang Province, China.
Lin C; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Jiang H; School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Xu X; Department of Orthopedics, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

BMC Musculoskelet Disord ; 24(1): 894, 2023 Nov 17.

Article em En | MEDLINE | ID: mdl-37978375

Assuntos

Eritropoetina; Necrose da Cabeça do Fêmur; Ratos; Animais; Caspase 3/metabolismo; Proteína X Associada a bcl-2/metabolismo; Necrose da Cabeça do Fêmur/induzido quimicamente; Necrose da Cabeça do Fêmur/tratamento farmacológico; Necrose da Cabeça do Fêmur/metabolismo; Citocromos c/metabolismo; Citocromos c/farmacologia; Microtomografia por Raio-X; Apoptose; Transdução de Sinais; Osteoblastos/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Eritropoetina/farmacologia; Esteroides/efeitos adversos

Palavras-chave

Apoptosis; Erythropoietin; Necrosis of the femoral head; STAT1-caspase 3

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Eritropoetina / Necrose da Cabeça do Fêmur Limite: Animals Idioma: En Revista: BMC Musculoskelet Disord Assunto da revista: FISIOLOGIA / ORTOPEDIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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