PSD-95 inhibitor Tat-NR2B9c (NA-1) protects the integrity of the blood-brain barrier after transient middle artery occlusion in rats by downregulating matrix metalloprotease-9 and upregulating endothelial nitric oxide synthase.

Xu, Ye; Xu, Lu; Xu, Chunfei; Zhao, Meiqi; Xu, Tong; Xia, Lingfan; Wu, Yucong; Cao, Yungang; Han, Zhao

Xu, Ye; Xu, Lu; Xu, Chunfei; Zhao, Meiqi; Xu, Tong; Xia, Lingfan; Wu, Yucong; Cao, Yungang; Han, Zhao.

Afiliação

Xu Y; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xu L; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xu C; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhao M; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xu T; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xia L; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wu Y; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Cao Y; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Han Z; Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: wzhanzhao@aliyun.com.

Brain Res Bull ; 206: 110836, 2024 Jan.

Article em En | MEDLINE | ID: mdl-38042504

Assuntos

Isquemia Encefálica; Fármacos Neuroprotetores; Peptídeos; Ratos; Masculino; Animais; Barreira Hematoencefálica/metabolismo; Isquemia Encefálica/metabolismo; Ratos Sprague-Dawley; Óxido Nítrico Sintase Tipo III/metabolismo; Células Endoteliais/metabolismo; Fármacos Neuroprotetores/farmacologia; Proteína 4 Homóloga a Disks-Large/metabolismo; Infarto Cerebral; Artérias/metabolismo; Metaloproteases/metabolismo; Infarto da Artéria Cerebral Média/metabolismo

Palavras-chave

Blood-brain barrier; Middle cerebral artery occlusion; Neuroprotection; PSD-95; Tat-NR2B9c (NA-1)

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Peptídeos / Isquemia Encefálica / Fármacos Neuroprotetores Limite: Animals Idioma: En Revista: Brain Res Bull Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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