Four new constituents from the fruits of <i>Cyclocodon lancifolius</i> (Roxburgh) Kurz.

Ma, Meng-Jie; Wu, Wei; Tian, Bei; Shen, Li-Ping; Wu, Tong; Huang, Chun-Yue; Mao, Xu-Dong; Hu, Xiao

Four new constituents from the fruits of Cyclocodon lancifolius (Roxburgh) Kurz.

Ma, Meng-Jie; Wu, Wei; Tian, Bei; Shen, Li-Ping; Wu, Tong; Huang, Chun-Yue; Mao, Xu-Dong; Hu, Xiao.

Afiliação

Ma MJ; State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China.
Wu W; Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Tian B; Guizhou Innovation Agriculture Development Co., Ltd, Tongren, China.
Shen LP; State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China.
Wu T; State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China.
Huang CY; State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China.
Mao XD; State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China.
Hu X; State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China.

Nat Prod Res ; : 1-10, 2023 Dec 06.

Article em En | MEDLINE | ID: mdl-38054801

ABSTRACT

ABSTRACT

Phytochemical analysis of the fruits of Cyclocodon lancifolius led to the isolation of two new phenylpropanoid-derived glycosides (1-2), two new geranyl glucosides (3-4), and nine known compounds (5-13). Their chemical structures were elucidated by extensive spectroscopic data. The absolute configuration of the sugar moiety was determined by hydrolysis and derivatization. All compounds were evaluated for their xanthine oxidase (XO) and α-glucosidase inhibitory activities, and four compounds showed weak inhibitory activity towards XO.

Palavras-chave

Cyclocodon lancifolius; geranyl glucoside; phenylpropanoid; xanthine oxidase; α-glucosidase

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China