Value-Based Search Efficiency Is Encoded in the Substantia Nigra Reticulata Firing Rate, Spiking Irregularity and Local Field Potential.
J Neurosci
; 44(6)2024 02 07.
Article
em En
| MEDLINE
| ID: mdl-38124002
ABSTRACT
Recent results show that valuable objects can pop out in visual search, yet its neural mechanisms remain unexplored. Given the role of substantia nigra reticulata (SNr) in object value memory and control of gaze, we recorded its single-unit activity while male macaque monkeys engaged in efficient or inefficient search for a valuable target object among low-value objects. The results showed that efficient search was concurrent with stronger inhibition and higher spiking irregularity in the target-present (TP) compared with the target-absent (TA) trials in SNr. Importantly, the firing rate differentiation of TP and TA trials happened within â¼100â
ms of display onset, and its magnitude was significantly correlated with the search times and slopes (search efficiency). Time-frequency analyses of local field potential (LFP) after display onset revealed significant modulations of the gamma band power with search efficiency. The greater reduction of SNr firing in TP trials in efficient search can create a stronger disinhibition of downstream superior colliculus, which in turn can facilitate saccade to obtain valuable targets in competitive environments.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Parte Reticular da Substância Negra
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
/
J. neurosci
/
Journal of neuroscience
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã