Development of a nomogram for predicting pharyngocutaneous fistula based on skeletal muscle mass and systemic inflammation indices.
Head Neck
; 46(3): 571-580, 2024 03.
Article
em En
| MEDLINE
| ID: mdl-38124665
ABSTRACT
BACKGROUND:
Laryngeal and hypopharyngeal cancers often require surgical treatment, which can lead to the development of pharyngocutaneous fistula (PCF). Our research aimed to assess the predictive value of skeletal muscle mass (SMM) and systemic inflammation indices for PCF and construct a clinically effective nomogram.METHODS:
A nested case-control study of 244 patients matched from 1171 patients with laryngeal or hypopharyngeal cancer was conducted. SMM was measured at the third cervical level based on CT scans. A PCF nomogram was developed based on the univariate and multivariate analyses.RESULTS:
Glucose, white blood cell count, platelet-to-lymphocyte ratio, and skeletal muscle index were independent risk factors for PCF. The area under the curve for the PCF nomogram was 0.841 (95% CI 0.786-0.897). The calibration and decision curves indicated that the nomogram was well-calibrated with good clinical utility.CONCLUSIONS:
The nomogram we constructed may help clinicians predict PCF risk early in the postoperative period, pending external validation.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofaríngeas
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Doenças Faríngeas
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Neoplasias Laríngeas
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Fístula Cutânea
Limite:
Humans
Idioma:
En
Revista:
Head & neck
/
Head Neck
/
Head neck
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China