Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability. / å«éèå¤å·´èºå
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J Zhejiang Univ Sci B
; 25(1): 65-82, 2024 Jan 15.
Article
em En, Zh
| MEDLINE
| ID: mdl-38163667
ABSTRACT
Magnesium-doped calcium silicate (CS) bioceramic scaffolds have unique advantages in mandibular defect repair; however, they lack antibacterial properties to cope with the complex oral microbiome. Herein, for the first time, the CS scaffold was functionally modified with a novel copper-containing polydopamine (PDA(Cu2+|)) rapid deposition method, to construct internally modified (*P), externally modified (@PDA), and dually modified (*P@PDA) scaffolds. The morphology, degradation behavior, and mechanical properties of the obtained scaffolds were evaluated in vitro. The results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical resistance. During the prolonged immersion stage, the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained release. The in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA, while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis effects. Finally, the PDA(Cu2+)-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect model. Overall, it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu2+) modification, and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Cobre
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Alicerces Teciduais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
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Zh
Revista:
J Zhejiang Univ Sci B
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J. Zhejiang Univ., Sci. B (Internet)
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Journal of Zhejiang University. Science B (Internet)
Assunto da revista:
BIOLOGIA
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MEDICINA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China