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Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.
Vance, Jeffery M; Farrer, Lindsay A; Huang, Yadong; Cruchaga, Carlos; Hyman, Bradley T; Pericak-Vance, Margaret A; Goate, Alison M; Greicius, Michael D; Griswold, Anthony J; Haines, Jonathan L; Tcw, Julia; Schellenberg, Gerard D; Tsai, Li-Huei; Herz, Joachim; Holtzman, David M.
Afiliação
  • Vance JM; John T. McDonald Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA.
  • Farrer LA; Departments of Medicine (Biomedical Genetics), Neurology and Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
  • Huang Y; Departments of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Cruchaga C; Department of Neurology, Gladstone Center for Translational Advancement, Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA, USA.
  • Hyman BT; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
  • Pericak-Vance MA; Alzheimer Research Unit, Department of Neurology, The Massachusetts General Hospital Institute for Neurodegenerative Disease, Harvard Medical School, Boston, MA, USA.
  • Goate AM; John T. McDonald Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA.
  • Greicius MD; Departments of Genetics & Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Griswold AJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Haines JL; John P. Hussman Institute for Human Genomics, The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Tcw J; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
  • Schellenberg GD; Departments of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston, MA, USA.
  • Tsai LH; Bioinformatics Program, Faculty of Computing & Data Sciences, Boston University, Boston, MA, USA.
  • Herz J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Holtzman DM; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ann Neurol ; 95(4): 625-634, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38180638
ABSTRACT
Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest genetic risk factor for AD. In 2023, the APOE4 National Institute on Aging/Alzheimer's Disease Sequencing Project working group came together to gather data and discuss the question of whether to reduce or increase APOE4 as a therapeutic intervention for AD. It was the unanimous consensus that cumulative data from multiple studies in humans and animal models support that lowering APOE4 should be a target for therapeutic approaches for APOE4 carriers. ANN NEUROL 2024;95625-634.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: America do norte Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: America do norte Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos