Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias.

Fowler-Shorten, Dominic J; Maynard, Rebecca S; Hampton, Katherine; Altera, Annalisa; Markham, Matthew; Ehikioya, Martha; Wojtowicz, Edyta E; Bowles, Kristian M; Rushworth, Stuart A; Hellmich, Charlotte

Fowler-Shorten, Dominic J; Maynard, Rebecca S; Hampton, Katherine; Altera, Annalisa; Markham, Matthew; Ehikioya, Martha; Wojtowicz, Edyta E; Bowles, Kristian M; Rushworth, Stuart A; Hellmich, Charlotte.

Afiliação

Fowler-Shorten DJ; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
Maynard RS; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
Hampton K; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
Altera A; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
Markham M; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
Ehikioya M; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ.
Wojtowicz EE; Earlham Institute, Norwich Research Park, Norwich, NR4 7UH.
Bowles KM; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Department of Haematology, Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, NR4 7UY.
Rushworth SA; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ. s.rushworth@uea.ac.uk.
Hellmich C; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, United Kingdom; Department of Haematology, Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich, NR4 7UY. c.hellmich@uea.ac.uk.

Haematologica ; 109(5): 1576-1581, 2024 May 01.

Article em En | MEDLINE | ID: mdl-38186347

Assuntos

Compostos Bicíclicos Heterocíclicos com Pontes; Células-Tronco Hematopoéticas; Interleucina-3; Leucemia Mieloide Aguda; Proteínas Proto-Oncogênicas c-bcl-2; Sulfonamidas; Humanos; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/patologia; Sulfonamidas/farmacologia; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Compostos Bicíclicos Heterocíclicos com Pontes/uso terapêutico; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/genética; Células-Tronco Hematopoéticas/metabolismo; Células-Tronco Hematopoéticas/efeitos dos fármacos; Interleucina-3/metabolismo; Regulação para Cima/efeitos dos fármacos; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Citopenia

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Sulfonamidas / Células-Tronco Hematopoéticas / Leucemia Mieloide Aguda / Interleucina-3 / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2024 Tipo de documento: Article

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