Ketone bodies in cell physiology and cancer.
Am J Physiol Cell Physiol
; 326(3): C948-C963, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38189128
ABSTRACT
Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy production. KBs can act as signaling metabolites, influence gene expression, proteins' posttranslational modifications (PTMs), inflammation, and oxidative stress. Here, we explore the impact of KBs on mammalian cell physiology, including aging and tissue regeneration. We also concentrate on KBs and cancer, given the extensive evidence that dietary approaches inducing ketosis, including fasting-mimicking diets (FMDs) and KDs, can prevent cancer and affect tumor progression.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Corpos Cetônicos
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Am J Physiol Cell Physiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos