Functional Cerebral Neurovascular Mapping During Focused Ultrasound Peripheral Neuromodulation of Neuropathic Pain.
IEEE Trans Biomed Eng
; 71(6): 1770-1779, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38198257
ABSTRACT
BACKGROUND:
Nociceptive pain is required for healthy function, yet, neuropathic pain (disease or injury) can be severely debilitating. Though a wide-array of treatment options are available, they are often systemic and/or invasive. As a promising neuromodulation treatment, Focused ultrasound (FUS) is a noninvasive and highly spatially-targeted technique shown to stimulate neural activity, yet, effects on pain signaling are currently unknown.OBJECTIVE:
Develop and validate a method for studying FUS nerve stimulation modulation of pain-evoked neural responses in vivo.METHODS:
We developed a high-resolution functional ultrasound (fUS) method capable of mapping cortical responses in healthy and neuropathic pain mice in response to FUS neuromodulation treatment.RESULTS:
FUS-evoked hemodynamic responses are correlated with the intensity of peripheral neuromodulation. We confirm functional connectivity is altered in neuropathic mice and demonstrate that FUS can modulate neuropathic pain-evoked hemodynamics.CONCLUSIONS:
The findings presented herein provides evidence for an FUS-based nerve pain method and validates the fUS technique developed for monitoring pain-evoked hemodynamics.SIGNIFICANCE:
We anticipate that the findings presented herein describe a noninvasive and flexible nerve modulation technique for pain mitigation, furthering evidence for clinical translation.
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Neuralgia
Limite:
Animals
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Ano de publicação:
2024
Tipo de documento:
Article