Targeting cancer stem cell plasticity in triple-negative breast cancer.
Explor Target Antitumor Ther
; 4(6): 1165-1181, 2023.
Article
em En
| MEDLINE
| ID: mdl-38213533
ABSTRACT
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Cancer stem cells (CSCs) are thought to play a crucial role in TNBC progression and resistance to therapy. CSCs are a small subpopulation of cells within tumors that possess self-renewal and differentiation capabilities and are responsible for tumor initiation, maintenance, and metastasis. CSCs exhibit plasticity, allowing them to switch between states and adapt to changing microenvironments. Targeting CSC plasticity has emerged as a promising strategy for TNBC treatment. This review summarizes recent advances in understanding the molecular mechanisms underlying CSC plasticity in TNBC and discusses potential therapeutic approaches targeting CSC plasticity.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Explor Target Antitumor Ther
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China