The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions.
Cancer Biomark
; 39(3): 223-230, 2024.
Article
em En
| MEDLINE
| ID: mdl-38217586
ABSTRACT
OBJECTIVE:
This article aims to investigate the clinical value of hemoglobin/red cell distribution width ratio (Hb/RDW), C-reactive protein/albumin ratio (CAR) and plateletcrit (PCT) combined with carcinoembryonic antigen (CEA) in colorectal cancer (CRC) auxiliary diagnosis.METHODS:
We retrospectively analyzed in 718 subjects (212 with CRC, 209 with benign colorectal lesions (BCL), 111 with other cancers, and 186 healthy controls).RESULTS:
The CAR, PCT, and CEA in the CRC group were higher than those in the BCL, other cancers, and the healthy control group. However, Hb/RDW in the CRC group was lower than the other three groups. Moreover, there were significant differences in Hb/RDW and CEA among different T-N-M stages (all P< 0.05). Multivariate logistic regression showed that low level of Hb/RDW and high level of CAR, CEA, PCT were risk factors for CRC, and are correlated with CRC stage. Additionally, the area under the receiver operating characteristic curve (AUC) of Hb/RDW+CEA (AUC 0.735), CAR+CEA (AUC 0.748), PCT+CEA (AUC 0.807) was larger than that of Hb/RDW (AUC 0.503), CAR (AUC 0.614), or PCT (AUC 0.713) alone (all P< 0.001) in distinguishing CRC from BCL.CONCLUSIONS:
Hb/RDW, CAR, PCT, and CEA are independent risk factors for CRC. Hb/RDW, CAR, and PCT combined with CEA have significant value for auxiliary differential diagnosis of CRC and BCL.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Antígeno Carcinoembrionário
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Cancer Biomark
Assunto da revista:
BIOQUIMICA
/
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article