Estimating utility values for non-alcoholic steatohepatitis health states: a discrete choice experiment.
J Comp Eff Res
; 13(2): e230033, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38226909
ABSTRACT
Background:
This study estimated utility values for non-alcoholic steatohepatitis (NASH). Previous studies have assumed that health-related quality of life does not vary between the early stages of NASH. Materials &Methods:
Discrete choice experiment (DCE) surveys estimated the value of avoiding fibrosis progression. Patients also completed the EQ-5D-5L. Marginal rates of substitution estimated utility change associated with fibrosis progression.Results:
DCE surveys were completed by the UK general public (n = 520) and patients with NASH (n = 154). The utility decline between fibrosis stages F1 and F4 decompensated was between -0.521 to -0.646 (depending on method).Conclusion:
Three methods were used to estimate utilities for NASH, each one showed sensitivity to advancing fibrosis, including in the early stages, which is often considered asymptomatic.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Qualidade de Vida
/
Hepatopatia Gordurosa não Alcoólica
Limite:
Humans
Idioma:
En
Revista:
J Comp Eff Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido