Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials.
Clin Transl Med
; 14(1): e1545, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-38264932
ABSTRACT
BACKGROUND:
The impact of fibroblasts on the immune system provides insight into the function of fibroblasts. In various tissue microenvironments, multiple fibroblast subtypes interact with immunocytes by secreting growth factors, cytokines, and chemokines, leading to wound healing, fibrosis, and escape of cancer immune surveillance. However, the specific mechanisms involved in the fibroblast-immunocyte interaction network have not yet been fully elucidated. MAIN BODY ANDCONCLUSION:
Therefore, we systematically reviewed the molecular mechanisms of fibroblast-immunocyte interactions in fibrosis, from the history of cellular evolution and cell subtype divisions to the regulatory networks between fibroblasts and immunocytes. We also discuss how these communications function in different tissue and organ statuses, as well as potential therapies targeting the reciprocal fibroblast-immunocyte interplay in fibrosis. A comprehensive understanding of these functional cells under pathophysiological conditions and the mechanisms by which they communicate may lead to the development of effective and specific therapies targeting fibrosis.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Citocinas
/
Fibroblastos
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Clin Transl Med
Ano de publicação:
2024
Tipo de documento:
Article