Development of artificial synapse organizers liganded with a peptide tag for molecularly inducible neuron-microelectrode interface.
Biochem Biophys Res Commun
; 699: 149563, 2024 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-38277728
ABSTRACT
It has been proposed that cell-type-specific bioelectronic interfaces for neuronal circuits could be established by utilizing the function of synapse organizers. For this purpose, using neurexin-1ß and a peptide tag, we engineered compact synapse organizers that do not interact with the naturally occurring receptors but induce presynaptic differentiation upon contact with nanobody-decorated objects in cultured mammalian and chick forebrain neurons. In chick neurons, the engineered organizer exerted synaptogenesis typically in â¼4 h after the contact, even under an air atmosphere at room temperature, thereby providing a useful cellular model for establishing the molecularly inducible neuron-microelectrode interface.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sinapses
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão