Comparison of the cost-effectiveness of sequential treatment with abaloparatide in US men and women at very high risk of fractures.
Aging Clin Exp Res
; 36(1): 14, 2024 Jan 30.
Article
em En
| MEDLINE
| ID: mdl-38289413
ABSTRACT
BACKGROUND:
Osteoporotic-related fractures represent an increasing burden to patients, health care systems and society.AIMS:
This study estimated cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) compared to relevant alternative strategies in US men and women aged 50 to 80 years at very high fracture risk (bone mineral density T-score ≤ - 2.5 and a recent fracture).METHODS:
A lifetime Markov-based microsimulation model was used to estimate healthcare costs and quality-adjusted life years (QALYs). Comparators were sequential treatment with unbranded teriparatide (TPTD)/ALN, generic ALN monotherapy, and no treatment. Analyses were conducted based on initial fracture site (hip, vertebral, or any fracture) and treatment efficacy data (derived from clinical trials or a recent network meta-analysis).RESULTS:
From all analyses completed, sequential ABL/ALN demonstrated more QALYs for lower healthcare costs versus unbranded TPTD/ALN. No treatment was dominated (higher costs for less QALYs) versus ALN monotherapy. Sequential ABL/ALN resulted in favorable cost-effectiveness (at US threshold of $150,000/QALY) versus generic ALN monotherapy in men aged ≥ 50 years with any fracture type, women aged ≥ 65 years with any fracture type, and women aged ≥ 55 years having a hip or vertebral fracture.DISCUSSION:
Similar cost-effectiveness of sequential ABL/ALN versus unbranded TPTD/ALN, ALN monotherapy, and no treatment was observed in both US men and women at very high fracture risk, with a moderate improvement in cost-effectiveness in men versus women and in patients with a hip or vertebral fracture.CONCLUSIONS:
Sequential therapy with ABL/ALN was cost-effective in US men and women at very high risk of fractures.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fraturas da Coluna Vertebral
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Fraturas por Osteoporose
Tipo de estudo:
Etiology_studies
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Health_economic_evaluation
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Aging Clin Exp Res
Assunto da revista:
GERIATRIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Holanda