Structure is beauty, but not always truth.
Cell
; 187(3): 517-520, 2024 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-38306978
ABSTRACT
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and "anti-targets." Overcoming these challenges will amplify the impact of structural biology on drug discovery.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
/
Biologia Molecular
Idioma:
En
Revista:
Cell
Ano de publicação:
2024
Tipo de documento:
Article