The association of prealbumin, transferrin, and albumin with immunosenescence among elderly males.
Aging Male
; 27(1): 2310308, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-38317318
ABSTRACT
OBJECTIVE:
As people get older, the innate and acquired immunity of the elderly are affected, resulting in immunosenescence. Prealbumin (PAB), transferrin (TRF), and albumin (ALB) are commonly used markers to monitor protein energy malnutrition (PEM). However, their relationship with the immune system has not been fully explored.METHODS:
In our study, a total of 93 subjects (≥65 years) were recruited from Tongji Hospital between January 2015 and February 2017. According to the serum levels of these proteins (PAB, TRF, and ALB), we divided the patients into the high serum protein group and the low serum protein group. Then, we compared the percent expression of lymphocyte subsets between two groups.RESULTS:
All the low serum protein groups (PAB, TRF, and ALB) had significant decreases in the percentage of CD4+ cells, CD3+CD28+ cells, CD4+CD28+ cells and significant increases in the percentage of CD8+ cells, CD8+CD28- cells. PAB, TRF, and ALB levels revealed positive correlations with CD4/CD8 ratio, proportions of CD4+ cells, CD3+CD28+ cells, CD4+CD28+ cells, and negative correlation with proportions of CD8+ cells, CD8+CD28- cells.CONCLUSIONS:
This study suggested PAB, TRF, and ALB could be used as immunosenescence indicators. PEM might accelerate the process of immunosenescence in elderly males.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Pré-Albumina
/
Imunossenescência
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Aging Male
Assunto da revista:
GERIATRIA
Ano de publicação:
2024
Tipo de documento:
Article