Sex difference and outcome trends following surgical aortic valve replacement from the National Inpatient Sample (NIS) Database.
J Cardiovasc Surg (Torino)
; 65(2): 161-168, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38332715
ABSTRACT
BACKGROUND:
Based on worldwide registries, approximately 50% of patients who underwent aortic valve replacement (AVR) via surgical aortic valve replacement are females. Although AVR procedures have improved greatly in recent years, differences in outcome including mortality between sexes remain. We aimed to investigate the trends in SAVR outcomes in females versus males.METHODS:
Using the 2011-2017 National Inpatient Sample (NIS) database, we identified hospitalizations for patients with diagnosis of aortic stenosis during which SAVR was performed. Patients' sociodemographic and clinical characteristics, procedure complications, and mortality were analyzed. Piecewise regression analyses were performed to assess temporal trends in SAVR utilization in females versus males. Multivariable analyses were performed to identify predictors of in-hospital mortality.RESULTS:
A total of 392,087 hospitalizations for SAVR across the USA were analyzed. Utilization of SAVR in both sex patients decreased significantly during the years 2011-2017. Males compared to females had significantly higher rates of hyperlipidemia, chronic renal disease, peripheral artery disease, coronary artery disease and tended to be smokers. Differences in mortality rates among sexes were observed for SAVR procedures. Women had higher in-hospital mortality with 3.7% compared to men with 2.5% (OR 1.38 [95% CI 1.33-1.43, P<0.001]). In a multivariable regression model analysis adjusted for potential confounders, women had higher mortality risk with odd ratio (OR 1.38 [95% CI 1.33-1.43], P<0.001). Women had significantly higher rates of vascular complications (5.1% compared to men with 4.6%, P=0.002).CONCLUSIONS:
Utilization of SAVR showed a downward trend during the study period. Higher in-hospital mortality was recorded in females compared to males.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Valva Aórtica
/
Estenose da Valva Aórtica
/
Bases de Dados Factuais
/
Mortalidade Hospitalar
/
Implante de Prótese de Valva Cardíaca
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Cardiovasc Surg (Torino)
/
J. cardiovasc. surg
/
Journal of cardiovascular surgery
Ano de publicação:
2024
Tipo de documento:
Article