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Associations between thyroid hormones and appendicular skeletal muscle index, and hand grip strength in people with diabetes: The KAMOGAWA-A study.
Hata, Shinnosuke; Okada, Hiroshi; Minamida, Megumi; Hironaka, Junya; Hasegawa, Yuka; Kondo, Yuriko; Nakajima, Hanako; Kitagawa, Nobuko; Okamura, Takuro; Hashimoto, Yoshitaka; Osaka, Takafumi; Kitagawa, Noriyuki; Majima, Saori; Senmaru, Takafumi; Ushigome, Emi; Nakanishi, Naoko; Asano, Mai; Hamaguchi, Masahide; Fukui, Michiaki.
Afiliação
  • Hata S; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Department of Endocrinology and Metabolism, Kyoto First Red Cross Hospital, Kyoto, Japan.
  • Okada H; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Japan. Electronic address: conti@koto.kpu-m.ac.jp.
  • Minamida M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Hironaka J; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Hasegawa Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Kondo Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Nakajima H; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Kitagawa N; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Okamura T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Hashimoto Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Japan.
  • Osaka T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Department of Diabetology, Kameoka Municipal Hospital, Kameoka, Japan.
  • Kitagawa N; Department of Endocrinology and Diabetology, Ayabe City Hospital, Ayabe, Japan.
  • Majima S; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Senmaru T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Ushigome E; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Nakanishi N; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Asano M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Division of Metabolism and Rheumatology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan.
  • Hamaguchi M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; Department of Endocrinology and Diabetology, Ayabe City Hospital, Ayabe, Japan.
  • Fukui M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Diabetes Res Clin Pract ; 209: 111573, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38346590
ABSTRACT

AIM:

To assess the effects of thyroid hormones on appendicular skeletal muscle index (SMI) and hand grip strength (HGS) in people with diabetes.

METHODS:

This cross-sectional cohort included 1,135 participants with diabetes admitted to 3 hospitals in Japan. Multiple regression analysis was performed to determine the associations among thyroid hormone levels, SMI, and HGS.

RESULTS:

Of the 1,135 participants, 480 were female. Their median (interquartile range) age, body mass index, durations of diabetes, and glycated haemoglobin levels were 68 years, 24.3 kg/m2, 10 years, and 7.6 %, respectively. The median (interquartile range) SMI (kg/m2) and hand grip strength of the cohort were 7.1 kg/m2 and 28.2 kg, respectively. Positive correlations between FT3 and the FT3/FT4 ratio with SMI and HGS was observed after adjusting for covariates in males. A negative correlation was found between the FT3/FT4 ratio and sarcopenia as a result of low SMI and low HGS in the male participants but not in females (p for interaction = 0.02).

CONCLUSIONS:

FT3/FT4 ratios may impact skeletal muscles in people with diabetes-particularly in males. Assessments of FT3/FT4 ratios may represent key indicators of muscle mass and strength in males.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus / Sarcopenia Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Diabetes Res Clin Pract Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Diabetes Mellitus / Sarcopenia Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Diabetes Res Clin Pract Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão