Progesterone and estradiol regulate sperm hyperactivation and in vitro fertilization success in mice.
J Reprod Dev
; 70(2): 96-103, 2024 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-38346725
ABSTRACT
Progesterone (P) and 17ß-estradiol (Eß) form the well-known hormone pair that regulates sperm capacitation. Here, we examined the regulatory effects of P and Eß on sperm hyperactivation in mice and evaluated the in vitro fertilization (IVF) success. Although P enhanced hyperactivation, Eß dose-dependently suppressed the P-enhanced hyperactivation. Moreover, P increased IVF success, whereas Eß suppressed the P-induced increase in IVF success in a dose-dependent manner. Thus, P and Eß competitively regulate hyperactivation and IVF success in mice. Since P and Eß concentrations generally change during the estrous cycle, sperm are speculated to capacitate in response to the oviductal environment and fertilize the oocyte.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Progesterona
/
Estradiol
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Reprod Dev
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão