Extended ischemic time (>15 hours) using controlled hypothermic storage in lung transplantation: A multicenter experience.
J Heart Lung Transplant
; 43(6): 999-1004, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38360161
ABSTRACT
Static ice storage has long been the standard-of-care for lung preservation, although freezing injury limits ischemic time (IT). Controlled hypothermic storage (CHS) at elevated temperature could safely extend IT. This retrospective analysis assesses feasibility and safety of CHS with IT > 15 hours. Three lung transplant (LuTx) centers (April-October 2023) included demographics, storage details, IT, and short-term outcome from 13 LuTx recipients (8 male, 59 years old). Donor lungs were preserved in a portable CHS device at 7 (5-9.3)°C. Indication was overnight bridging and/or long-distance transport. IT of second-implanted lung was 17.3 (15.1-22) hours. LuTx were successful, 4/13 exhibited primary graft dysfunction grade 3 within 72 hours and 0/13 at 72 hours. Post-LuTx mechanical ventilation was 29 (7-442) hours. Intensive care unit stay was 9 (5-28) and hospital stay 30 (16-90) days. Four patients needed postoperative extracorporeal membrane oxygenation (ECMO). One patient died (day 7) following malpositioning of an ECMO cannula. This multicenter experience demonstrates the possibility of safely extending IT > 15 hours by CHS.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Preservação de Órgãos
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Transplante de Pulmão
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Heart Lung Transplant
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J. heart lung transplant
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Journal of heart and lung transplantation
Assunto da revista:
CARDIOLOGIA
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TRANSPLANTE
Ano de publicação:
2024
Tipo de documento:
Article