Blood and guts: how the intestinal microbiome shapes hematopoiesis and treatment of hematologic disease.
Blood
; 143(17): 1689-1701, 2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38364184
ABSTRACT
ABSTRACT Over the past 10 years, there has been a marked increase in recognition of the interplay between the intestinal microbiome and the hematopoietic system. Despite their apparent distance in the body, a large literature now supports the relevance of the normal intestinal microbiota to steady-state blood production, affecting both hematopoietic stem and progenitor cells as well as differentiated immune cells. Microbial metabolites enter the circulation where they can trigger cytokine signaling that influences hematopoiesis. Furthermore, the state of the microbiome is now recognized to affect outcomes from hematopoietic stem cell transplant, immunotherapy, and cellular therapies for hematologic malignancies. Here we review the mechanisms by which microbiotas influence hematopoiesis in development and adulthood as well as the avenues by which microbiotas are thought to impact stem cell transplant engraftment, graft-versus-host disease, and efficacy of cell and immunotherapies. We highlight areas of future research that may lead to reduced adverse effects of antibiotic use and improved outcomes for patients with hematologic conditions.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Microbioma Gastrointestinal
/
Doenças Hematológicas
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Hematopoese
Limite:
Animals
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Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2024
Tipo de documento:
Article