Quantitative characterization of run-and-tumble statistics in bulk bacterial suspensions.
Phys Rev E
; 109(1-1): 014612, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38366485
ABSTRACT
We introduce a numerical method to extract the parameters of run-and-tumble dynamics from experimental measurements of the intermediate scattering function. We show that proceeding in Laplace space is unpractical and employ instead renewal processes to work directly in real time. We first validate our approach against data produced using agent-based simulations. This allows us to identify the length and time scales required for an accurate measurement of the motility parameters, including tumbling frequency and swim speed. We compare different models for the run-and-tumble dynamics by accounting for speed variability at the single-cell and population level, respectively. Finally, we apply our approach to experimental data on wild-type Escherichia coli obtained using differential dynamic microscopy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bactérias
/
Microscopia
Idioma:
En
Revista:
Phys Rev E
/
Phys. rev., E (Online)
/
Physical review. E (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China