Exposure to the plasticizer diisopentyl phthalate can cause Vero cell line death.
Food Chem Toxicol
; 186: 114521, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38369054
ABSTRACT
Phthalates are synthetic plasticizers present in the daily lives of humans, as part of the composition of different products, such as food packaging, water bottles, and toys. These compounds can migrate from plastic materials to the environment changing biological systems. Although diisopentyl phthalate (DiPeP) is largely used in Brazil, there is a lack of information on the possible toxic effects of this compound. This research aims to evaluate the toxicity of DiPeP in the Vero renal cells. These cells were exposed to the 1-1000 µM of DiPeP for 24 and 72 h and subsequently, the cytotoxicity, apoptosis and necrosis-inducing potential, and antioxidant system (SOD, GPx, and GST) were investigated. DiPeP neither caused cytotoxicity nor altered SOD and GPx activity, although GST has been increased at 100 or 1 µM (24 and 72 h, respectively). However, cell death by apoptosis and necrosis was observed. These results indicate that DiPeP caused cell death by a non-oxidative stress-mediated mechanism, which shows the relevance of investigate other process in further researches.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ácidos Ftálicos
/
Dietilexilftalato
Limite:
Humans
Idioma:
En
Revista:
Food Chem Toxicol
/
Food and chemical toxicology
/
Food chem. toxicol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil