A pilot study proposing an algorithm for pubertal induction in cerebral palsy.
J Pediatr Endocrinol Metab
; 37(3): 222-227, 2024 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-38374118
ABSTRACT
OBJECTIVES:
To explore delayed puberty in cerebral palsy (CP) and to test the acceptability of an interventional puberty induction algorithm.METHODS:
A two phase cohort study in children and adolescents diagnosed with CP who have delayed puberty. Phase 1 Retrospective review of clinical records and interviews with patients who have been treated with sex-steroids and Phase 2 Prospective interventional trial of pubertal induction with a proposed algorithm of transdermal testosterone (males) or oestrogen (females). Phase 1 examined experiences with sex-steroid treatment. Phase 2 collected data on height adjusted bone mineral density (BMAD), fractures, adverse effects, mobility and quality of life over two years during the induction.RESULTS:
Phase 1, treatment was well tolerated in 11/20 treated with sex-steroids; phase 2, using the proposed induction algorithm, 7/10 treated reached Tanner stage 3 by nine months. One participant reached Tanner stage 5 in 24 months. Mean change in BMAD Z-scores was +0.27â¯% (SD 0.002) in those who could be scanned by dual-energy X-ray absorptiometry (DXA).CONCLUSIONS:
Delayed puberty may be diagnosed late. Treatment was beneficial and well tolerated, suggesting all patients with severe pubertal delay or arrest should be considered for sex hormone supplementation.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Puberdade Tardia
/
Paralisia Cerebral
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália