Cohesin regulation and roles in chromosome structure and function.
Curr Opin Genet Dev
; 85: 102159, 2024 04.
Article
em En
| MEDLINE
| ID: mdl-38382406
ABSTRACT
Chromosome structure regulates DNA-templated processes such as transcription of genes. Dynamic changes to chromosome structure occur during development and in disease contexts. The cohesin complex is a molecular motor that regulates chromosome structure by generating DNA loops that bring two distal genomic sites into close spatial proximity. There are many open questions regarding the formation and dissolution of DNA loops, as well as the role(s) of DNA loops in regulating transcription of the interphase genome. This review focuses on recent discoveries that provide molecular insights into the role of cohesin and chromosome structure in gene transcription during development and disease.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Proteínas de Ciclo Celular
/
Coesinas
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos