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Versatile roles of cysteine persulfides in tumor biology.
Borbényi-Galambos, Klaudia; Czikora, Ágnes; Erdélyi, Katalin; Nagy, Péter.
Afiliação
  • Borbényi-Galambos K; Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, 1122, Hungary; Kálmán Laki Doctoral School, University of Debrecen, Debrecen, Hajdú-Bihar County, 4032, Hungary.
  • Czikora Á; Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, 1122, Hungary.
  • Erdélyi K; Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, 1122, Hungary.
  • Nagy P; Department of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, 1122, Hungary; Department of Anatomy and Histology, HUN-REN-UVMB Laboratory of Redox Biology Research Group, University of Veterinary Medicine, Budapest, 1078, Hunga
Curr Opin Chem Biol ; 79: 102440, 2024 04.
Article em En | MEDLINE | ID: mdl-38422870
ABSTRACT
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in cancer cells to support their increased cysteine demand and to produce Reactive Sulfur Species (RSS) including hydrogen sulfide (H2S) and cysteine persulfide. This can directly (via RSS) or indirectly (by supplying Cys) trigger chemical or enzyme catalyzed persulfidation on critical protein cysteine residues to protect them from oxidative damage and to orchestrate protein functions, and thereby contribute to cancer cell plasticity. In this review key aspects of persulfide-mediated biological processes are highlighted and critically discussed in relation to cancer cell survival, bioenergetics, proliferation as well as in tumor angiogenesis, adaptation to hypoxia and oxidative stress, and regulation of epithelial to mesenchymal transition.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Cisteína / Dissulfetos / Transição Epitelial-Mesenquimal Idioma: En Revista: Curr Opin Chem Biol Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Hungria

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Cisteína / Dissulfetos / Transição Epitelial-Mesenquimal Idioma: En Revista: Curr Opin Chem Biol Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Hungria