Four New Isocoumarins from the Mangrove Fungus Alternaria Malorum with Antimicrobial Activities.
Chem Biodivers
; 21(6): e202400327, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38446672
ABSTRACT
Four new isocoumarins, alternariethers A-C (1-3) and alternariester (4) were separated from the fermentation of the fungus Alternaria malorum FL39, purified from Myoporum bontioides. Their structures were ascertained using NMR and HR-ESI-MS spectroscopy. For compoundâ
4, the absolute configuration was solved with the help of ECD calculation and the DP4+ method. Compared with the positive control triadimefon, compoundâ
1 showed more potent antifungal effects on Colletotrichum musae. The antifungal effects of compoundsâ
1, 2, and 3 on Fusarium oxysporum and Fusarium graminearum, of compoundâ
4 on F. oxysporum, were equal to those of triadimefon. Except for compoundâ
4 which was inactive against Escherichia coli with O78 serotype, all compounds showed moderate or weak antibacterial activity against Staphylococcus aureus ATCC 6538 and E. coli with O6 or O78 serotype.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Testes de Sensibilidade Microbiana
/
Escherichia coli
/
Isocumarinas
/
Alternaria
/
Fusarium
/
Antibacterianos
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China