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Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy.
Wang, Sisi; Gai, Lizhi; Chen, Yuncong; Ji, Xiaobo; Lu, Hua; Guo, Zijian.
Afiliação
  • Wang S; College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and Key Laboratory of Organosilicon Material Technology of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China. hualu@hznu.edu.cn.
  • Gai L; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. zguo@nju.edu.cn.
  • Chen Y; State Key Laboratory of Powder Metallurgy, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
  • Ji X; College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and Key Laboratory of Organosilicon Material Technology of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China. hualu@hznu.edu.cn.
  • Lu H; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. zguo@nju.edu.cn.
  • Guo Z; State Key Laboratory of Powder Metallurgy, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Chem Soc Rev ; 53(8): 3976-4019, 2024 Apr 22.
Article em En | MEDLINE | ID: mdl-38450547
ABSTRACT
Mitochondria are essential for a diverse array of biological functions. There is increasing research focus on developing efficient tools for mitochondria-targeted detection and treatment. BODIPY dyes, known for their structural versatility and excellent spectroscopic properties, are being actively explored in this context. Numerous studies have focused on developing innovative BODIPYs that utilize optical signals for imaging mitochondria. This review presents a comprehensive overview of the progress made in this field, aiming to investigate mitochondria-related biological events. It covers key factors such as design strategies, spectroscopic properties, and cytotoxicity, as well as mechanism to facilitate their future application in organelle imaging and targeted therapy. This work is anticipated to provide valuable insights for guiding future development and facilitating further investigation into mitochondria-related biological sensing and phototherapy.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fotoquimioterapia / Compostos de Boro / Corantes Fluorescentes / Mitocôndrias Limite: Animals / Humans Idioma: En Revista: Chem Soc Rev Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fotoquimioterapia / Compostos de Boro / Corantes Fluorescentes / Mitocôndrias Limite: Animals / Humans Idioma: En Revista: Chem Soc Rev Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China