IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation.
Blood
; 143(18): 1873-1877, 2024 May 02.
Article
em En
| MEDLINE
| ID: mdl-38457663
ABSTRACT
ABSTRACT High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Imunidade Inata
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Isocitrato Desidrogenase
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Mutação
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Blood
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália