Association between echocardiographic indexes and urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in dogs with myxomatous mitral valve disease.
Res Vet Sci
; 171: 105211, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38458044
ABSTRACT
Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of tubular damage, and its elevation has been described in human and canine cardiorenal syndrome. The aim was to evaluate the association between echocardiographic indexes and urine NGAL (uNGAL) and uNGAL normalized to urine creatinine (uNGALC) in dogs with MMVD. This is a multicentric prospective cross-sectional study. A total of 77 dogs with MMVD at different ACVIM stages were included. All dogs underwent echocardiography, serum chemistry, and urinalysis. Echocardiographic data analyzed were shortening fraction (SF), left ventricular diastolic (LVIDDn) and systolic (LVIDSn) diameters normalized for body weight, left atrium to aortic root ratio (LA/Ao), maximal (LAVMax) and minimal (LAVMin) left atrial volumes, LA stroke volume (LASV), early diastolic mitral peak velocity (EVmax), EVmax to tissue Doppler E' wave (E/E'), aortic (VTIAo) and mitralic (VTIMit) velocity time integrals and their ratio (VTIMit/VTIAo), and tricuspid regurgitation velocity (TRVmax). In the univariate analysis LASV, TRVmax, LAVMax, LVIDDn, and VTIMit/VTIAo were independent predictors of increased uNGAL and uNGALC; however, only LASV [(OR 1.96, 95% CI 1.16 to 3.31) P = 0.01 for NGAL, and (OR 2.79, 95% CI 1.50 to 5.17) P < 0.001 for NGALC] and TRVmax [(OR 1.73, 95% CI 1.20-2.51) P = 0.002 for NGAL, and (OR 1.50, 95% CI 10.07-2.10) P = 0.015 for NGALC] remained statistically significant in the multivariable analysis. Based on our results, LASV and TRVmax are associated with increased uNGAL and uNGALC. These parameters might detect dogs with MMVD at higher risk of developing kidney damage.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Doenças do Cão
/
Doenças das Valvas Cardíacas
Limite:
Animals
Idioma:
En
Revista:
Res Vet Sci
/
Res. vet. sci
/
Research in veterinary science
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália